Evolve Pharmacology Practice Test 2025 – Complete Exam Preparation

Opioid analgesics are commonly used for their pain-relieving properties, but they also come with a range of adverse effects due to their action on the central nervous system and gastrointestinal tract. One of the most significant and commonly noted adverse effects is constipation.

Opioids bind to specific receptors in the gastrointestinal (GI) tract, which leads to a decrease in gut motility. This slowing down of the gut can result in hardening of stools and increased difficulty in passing them, thereby causing constipation. It is particularly problematic as it can lead to discomfort and further complications if not managed appropriately.

While drowsiness, nausea, and dry mouth can certainly occur with opioid use, they are often less consistent across patients. Constipation is almost universally experienced by individuals on chronic opioid therapy, making it a defining adverse effect that healthcare providers need to monitor and manage actively. This awareness prompts both providers and patients to anticipate and address this issue proactively when opioids are prescribed for pain management.